Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors-Reference-Cited by-同舟云学术

Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors

Published:2023-07 Issue: Volume:91 Page:129352
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Grimster Neil P.,Gingipalli Lakshmaiah,Balazs Amber,Barlaam Bernard,Boiko Scott,Boyd Scott,Dry Hannah,Goldberg Frederick W.,Ikeda Tim,Johnson Tony,Kawatkar Sameer,Kemmitt Paul^ORCID,Lamont Scott,Lorthioir Olivier,Mfuh Adelphe,Patel Joe^ORCID,Pike Andy,Read Jon,Romero Romulo,Sarkar Ujjal,Sha Li,Simpson Iain,Song Kun^ORCID,Su Qibin,Wang Haixia,Watson David,Wu Allan,Zehnder Troy E.,Zheng XiaoLan,Li Shaolu,Dong Zhiqiang,Yang Dejian,Song Yanwei,Wang Peng,Liu Xuemei,Dowling James E.,Edmondson Scott D.^ORCID

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference27 articles.

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2. Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex;Law;J Biol Chem,1994

3. The structure and function of nonreceptor tyrosine kinase p72syk expressed in hematopoietic cells;Yanagi;Cell Signal,1995

4. Molecular mechanism of the Syk activation switch;Tsang;J Biol Chem,2008

5. SYK as a new therapeutic target in B-Cell precursor acute lymphoblastic leukemia;Uckun;J Cancer Ther,2014

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1. Spleen tyrosine kinase (SYK): an emerging target for the assemblage of small molecule antitumor agents;Expert Opinion on Investigational Drugs;2024-08-11

2. Discovery of Selective SYK Inhibitors by the Macrocyclization and Prodrug Approaches;Synfacts;2023-08-16