Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: Discovery of PF-3084014-Reference-Cited by-同舟云学术

Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: Discovery of PF-3084014

Published:2011-05 Issue:9 Volume:21 Page:2637-2640
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Brodney Michael A.,Auperin David D.,Becker Stacey L.,Bronk Brian S.,Brown Tracy M.,Coffman Karen J.,Finley James E.,Hicks Carol D.,Karmilowicz Michael J.,Lanz Thomas A.,Liston Dane,Liu Xingrong,Martin Barbara-Anne,Nelson Robert B.,Nolan Charles E.,Oborski Christine E.,Parker Christine P.,Richter Karl E.G.,Pozdnyakov Nikolay,Sahagan Barbara G.,Schachter Joel B.,Sokolowski Sharon A.,Tate Barbara,Wood Douglas E.,Wood Kathleen M.,Van Deusen Jeffrey W.,Zhang Lei

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference14 articles.

1. γ-secretases: from cell biology to therapeutic strategies

2. Cellular mechanisms of beta -amyloid production and secretion

3. The γ-Secretase Complex: Membrane-Embedded Proteolytic Ensemble

4. Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation

5. The role of notch signaling in the development of a normal B‐cell repertoire

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