Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach-Reference-Cited by-同舟云学术

Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach

Published:2009-08 Issue:15 Volume:19 Page:4509-4514
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Beswick Paul J.,Blackaby Andrew P.,Bountra Chas,Brown Terry,Browning Kerry,Campbell Ian B.,Corfield John,Gleave Robert J.,Guntrip Steve B.,Hall Richard M.,Hindley Sean,Lambeth Paul F.,Lucas Fiona,Mathews Neil,Naylor Alan,Player Hazel,Price Helen S.,Sidebottom Phillip J.,Taylor Nicholas L.,Webb Graham,Wiseman Joanne

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference7 articles.

1. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

2. Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors

3. Biotransformations: Preparative Organic Chemistry;Roberts,1989

4. Microbial models of mammalian metabolism. Aromatic hydroxylation

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