Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays-Reference-Cited by-同舟云学术

Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays

Published:2020-03 Issue:5 Volume:30 Page:126929
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Ren Albert,Zhu Xiuwen,Feichtinger Konrad,Lehman Juerg,Kasem Michelle,Schrader Thomas O.,Wong Amy,Dang Huong,Le Minh,Frazer John,Unett David J.,Grottick Andrew J.,Whelan Kevin T.,Morgan Michael E.,Sage Carleton R.,Semple Graeme^ORCID

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference23 articles.

1. Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity;Halford;Curr Drug Targets,2005

2. Serotonin 5-HT2C receptor agonists: potential for the treatment of obesity;Miller;Mol Int,2005

3. Reduced satiating effect of d-fenfluramine in serotonin 5-HT(2C) receptor mutant mice;Vickers;Psychopharmacology,1999

4. Valvular heart disease associated with fenfluramine–phentermine;Connolly;New Engl J Med,1997

5. Evidence for possible involvement of 5-HT2B receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications;Rothman;Circulation,2000

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