Ketopiperazine-based renin inhibitors: Optimization of the “C” ring-Reference-Cited by-同舟云学术

Ketopiperazine-based renin inhibitors: Optimization of the “C” ring

Published:2006-05 Issue:9 Volume:16 Page:2500-2504
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Holsworth Daniel D.,Cai Cuiman,Cheng Xue-Min,Cody Wayne L.,Downing Dennis M.,Erasga Noe,Lee Chitase,Powell Noel A.,Edmunds Jeremy J.,Stier Michael,Jalaie Mehran,Zhang Erli,McConnell Pat,Ryan Michael J.,Bryant John,Li Tingsheng,Kasani Aparna,Hall Eric,Subedi Rajendra,Rahim Mohammad,Maiti Samarendra

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference15 articles.

1. Review: Potential of renin inhibition in cardiovascular disease

2. The Future of Angiotensin II Inhibition in Cardiovascular Medicine

3. Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats

4. Substituted piperidines - highly potent renin inhibitors due to induced fit adaptation of the active site

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