Substituted piperidines - highly potent renin inhibitors due to induced fit adaptation of the active site-Reference-Cited by-同舟云学术

Substituted piperidines - highly potent renin inhibitors due to induced fit adaptation of the active site

Published:1999-05 Issue:10 Volume:9 Page:1397-1402
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Vieira Eric,Binggeli Alfred,Breu Volker,Bur Daniel,Fischli Walter,Güller Rolf,Hirth Georges,Märki Hans Peter,Müller Marcel,Oefner Christian,Scalone Michelangelo,Stadler Heinz,Wihelm Maurice,Wostl Wolfgang

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference21 articles.

1. Maintenance of blood pressure by the renin–angiotensin system in normal man

2. Blood pressure effects of acute intravenous renin or oral angiotensin converting enzyme inhibition in essential hypertension

3. Immediate blood pressure effects of the renin inhibitor enalkiren and the angiotensin-converting enzyme inhibitor enalaprilat

4. Clinical Experience With the Angiotensin II Receptor Antagonist Losartan

Cited by 101 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. 1,4-Dimethoxynaphthalene-2-methyl (‘DIMON’), an oxidatively labile protecting group for synthesis of polyunsaturated lipids;Chemical Communications;2023

2. Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor;Journal of Medicinal Chemistry;2022-08-08

3. Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors;ACS Medicinal Chemistry Letters;2022-08-01

4. Exploiting Structural Dynamics To Design Open-Flap Inhibitors of Malarial Aspartic Proteases;Journal of Medicinal Chemistry;2019-05-07

5. Identification of novel human renin inhibitors through a combined approach of pharmacophore modelling, molecular DFT analysis and in silico screening;Computational Biology and Chemistry;2017-08