A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors-Reference-Cited by-同舟云学术

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A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors

Published:2010-01 Issue:1 Volume:20 Page:153-156
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Wang Tiansheng,Ledeboer Mark W.,Duffy John P.,Pierce Albert C.,Zuccola Harmon J.,Block Eric,Shlyakter Dina,Hogan James K.,Bennani Youssef L.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference17 articles.

1. JAK protein kinase inhibitors

3. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

4. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

5. A Gain-of-Function Mutation ofJAK2in Myeloproliferative Disorders

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5. Diastereoselective Synthesis of Spiro[indoline‐3,7′‐pyrrolo[1,2‐ a ]azepines] via Sequential [3+2] Cycloaddition and Ring Expansion Reaction;Asian Journal of Organic Chemistry;2020-09-21

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