Discovery and initial optimization of 5,5′-disubstituted aminohydantoins as potent β-secretase (BACE1) inhibitors-Reference-Cited by-同舟云学术

Discovery and initial optimization of 5,5′-disubstituted aminohydantoins as potent β-secretase (BACE1) inhibitors

Published:2010-01 Issue:2 Volume:20 Page:632-635
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Nowak Pawel,Cole Derek C.,Aulabaugh Ann,Bard Jonathan,Chopra Rajiv,Cowling Rebecca,Fan Kristi Y.,Hu Baihua,Jacobsen Steve,Jani Minakshi,Jin Guixan,Lo Mei-Chu,Malamas Michael S.,Manas Eric S.,Narasimhan Rani,Reinhart Peter,Robichaud Albert J.,Stock Joseph R.,Subrath Joan,Svenson Kristine,Turner Jim,Wagner Erik,Zhou Ping,Ellingboe John W.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference27 articles.

1. Forecasting the global burden of Alzheimer's disease

2. Clinical Diagnosis and Management of Alzheimer’s Disease;Blass,1996

3. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

4. Alzheimer's Disease: Genes, Proteins, and Therapy

5. Progress toward the development of a viable BACE-1 inhibitor

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