Progress toward the development of a viable BACE-1 inhibitor

Author:

Stachel Shawn J.

Publisher

Wiley

Subject

Drug Discovery

Reference39 articles.

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2. Albert J, Chessari G, Edwards P. 2007b. Preparation of substituted 2-aminopyrimidines for treating or preventing Ab-related pathologies. WO patent 2007058581. Astrazeneca AB S, Astex Therapeutics Ltd.

3. Alzheimer's Disease Facts and Figures. 2007. www.alz.org/alzheimersdisease_publications_reports. in press.

4. The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice;Asai;J Neurochem,2006

5. 2-amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): use of structure based design to convert a micromolar hit into a nanomolar lead;Baxter;J Med Chem,2007

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