Structure–activity relationship (SAR) studies on substituted N-(pyridin-3-yl)-2-amino-isonicotinamides as highly potent and selective glycogen synthase kinase-3 (GSK-3) inhibitors-Reference-Cited by-同舟云学术

Structure–activity relationship (SAR) studies on substituted N-(pyridin-3-yl)-2-amino-isonicotinamides as highly potent and selective glycogen synthase kinase-3 (GSK-3) inhibitors

Published:2023-02 Issue: Volume:81 Page:129143
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Luo Guanglin^ORCID,Chen Ling,Jacutin-Porte Swanee,Han Ying,Burton Catherine R.,Xiao Hong,Krause Carol M.,Cao Yang,Liu Nengyin,Kish Kevin,Lewis Hal A.,Macor John E.,Dubowchik Gene M.^ORCID

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference28 articles.

1. Molecular cloning and expression of glycogen synthase kinase-3/factor A;Woodgett;EMBO J,1990

2. The multifaceted roles of glycogen synthase kinase 3ß in cellular signaling;Grimes;Prog Neurobiol,2001

3. Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain;Pei;J Neuropathol Exp Neurol,1997

4. Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes;Pei;J Neuropathol Exp Neurol,1999

5. Functional implications of glycogen synthase kinase-3-mediated Tau phosphorylation;Hanger;Int J Alzheimer’s Dis,2011

Cited by 5 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Targeting glycogen synthase kinase-3β for Alzheimer's disease: Recent advances and future Prospects;European Journal of Medicinal Chemistry;2024-02

2. Design, synthesis, and biological evaluation of N-(pyridin-3-yl)pyrimidin-4-amine analogues as novel cyclin-dependent kinase 2 inhibitors for cancer therapy;Bioorganic Chemistry;2024-02

3. Targeting protein kinases for the treatment of Alzheimer's disease: Recent progress and future perspectives;European Journal of Medicinal Chemistry;2023-12

4. Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors;Journal of Medicinal Chemistry;2023-05-26

5. Design, Structure–Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2-b]pyridazines as Glycogen Synthase Kinase-3β (GSK-3β) Inhibitors;Journal of Medicinal Chemistry;2023-03-09