Discovery of novel quinoline sulphonamide derivatives as potent, selective and orally active RORγ inverse agonists-Reference-Cited by-同舟云学术

Discovery of novel quinoline sulphonamide derivatives as potent, selective and orally active RORγ inverse agonists

Published:2019-07 Issue:14 Volume:29 Page:1799-1806
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Amaudrut Jérôme,Argiriadi Maria A.,Barth Martine,Breinlinger Eric C.,Bressac Didier,Broqua Pierre,Calderwood David J.,Chatar Mohamed,Cusack Kevin P.,Gauld Stephen B.,Jacquet Sébastien,Kamath Rajesh V.,Kort Michael E.,Lepais Valérie,Luccarini Jean-Michel,Masson Philippe,Montalbetti Christian,Mounier Laurent,Potin Dominique,Poupardin Olivia,Rouaud Sylvie,Spitzer Luc,Wallace Craig D.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference30 articles.

2. Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism

3. IL-17-producing γδ T cells and innate lymphoid cells

4. Structural Basis for Hydroxycholesterols as Natural Ligands of Orphan Nuclear Receptor RORγ

5. See Supplementary Data for examples of RORγ LBD showing water molecules in the polar area close to arginines.

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