Allosteric inhibitors of Akt1 and Akt2: Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity-Reference-Cited by-同舟云学术

Allosteric inhibitors of Akt1 and Akt2: Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity

Published:2009-02 Issue:3 Volume:19 Page:834-836
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Li Yiwei,Liang Jun,Siu Tony,Hu Essa,Rossi Michael A.,Barnett Stanley F.,Defeo-Jones Deborah,Jones Raymond E.,Robinson Ronald G.,Leander Karen,Huber Hans E.,Mittal Sachin,Cosford Nicholas,Prasit Peppi

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference27 articles.

1. The Phosphoinositide 3-Kinase Pathway

2. The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

3. Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery

4. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

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