Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries-Reference-Cited by-同舟云学术

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Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries

Published:2004-12 Issue:24 Volume:14 Page:6083-6087
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Leahy Justin J.J.,Golding Bernard T.,Griffin Roger J.,Hardcastle Ian R.,Richardson Caroline,Rigoreau Laurent,Smith Graeme C.M.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference17 articles.

1. Sensing and repairing DNA double-strand breaks

2. The DNA-dependent protein kinase

3. Requirement for the Kinase Activity of Human DNA-Dependent Protein Kinase Catalytic Subunit in DNA Strand Break Rejoining

Cited by 353 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Simultaneous inhibition of ATM, ATR, and DNA-PK causes synergistic lethality;Biochemical and Biophysical Research Communications;2024-12

2. Development and therapeutic potential of DNA-dependent protein kinase inhibitors;Bioorganic Chemistry;2024-09

3. Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441;Scientific Reports;2024-08-28

4. Topological stress triggers persistent DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment;2024-08-19

5. Distinct regulation of ATM signaling by DNA single-strand breaks and APE1;Nature Communications;2024-08-07

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