Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441-Reference-Cited by-同舟云学术

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Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441

Published:2024-08-28 Issue:1 Volume:14 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Waldrip Zachary J.,Acharya Baku,Armstrong Daniel,Hanafi Maha,Rainwater Randall R.,Amole Sharon,Fulmer Madeline,Azevedo-Pouly Ana Clara,Burns Alaina,Burdine Lyle,Frett Brendan,Burdine Marie Schluterman

Funder

National Institutes of Health

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41598-024-70858-w.pdf

Reference25 articles.

1. Yue, X., Bai, C., Xie, D., Ma, T. & Zhou, P.-K. DNA-PKcs: A multi-faceted player in DNA damage response. Front. Genet. https://doi.org/10.3389/fgene.2020.607428 (2020).

2. Tsai, A. K. et al. A multikinase and DNA-PK inhibitor combination immunomodulates melanomas, suppresses tumor progression, and enhances immunotherapies. Cancer Immunol. Res. 5(9), 790–803. https://doi.org/10.1158/2326-6066.CIR-17-0009 (2017).

3. Cheng, B. et al. Recent advances in DDR (DNA damage response) inhibitors for cancer therapy. Eur. J. Med. Chem. 230, 114109. https://doi.org/10.1016/j.ejmech.2022.114109 (2022).

4. Carr, M. I. et al. DNA-PK inhibitor, M3814, as a new combination partner of mylotarg in the treatment of acute myeloid leukemia. Front. Oncol. https://doi.org/10.3389/fonc.2020.00127 (2020).

5. Migliozzi, S. et al. Integrative multi-omics networks identify PKCδ and DNA-PK as master kinases of glioblastoma subtypes and guide targeted cancer therapy. Nat. Cancer 4(2), 181–202. https://doi.org/10.1038/s43018-022-00510-x (2023).

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