Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2 H -pyrrol-2-one actives verified by ALARM NMR-Reference-Cited by-同舟云学术

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Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2 H -pyrrol-2-one actives verified by ALARM NMR

Published:2015-11 Issue:21 Volume:25 Page:4740-4752
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Dahlin Jayme L.,Nissink J. Willem M.,Francis Subhashree,Strasser Jessica M.,John Kristen,Zhang Zhiguo,Walters Michael A.

Funder

Minnesota Partnership for Biotechnology and Medical Genomics

NIH

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference96 articles.

1. The essential roles of chemistry in high-throughput screening triage

2. A Case Study from the Chemistry Core of the Pittsburgh Molecular Library Screening Center: The Polo-like Kinase Polo-Box Domain (Plk1- PBD)

3. The Identification, Characterization and Optimization of Small Molecule Probes of Cysteine Proteases: Experiences of the Penn Center for Molecular Discovery with Cathepsin B and Cathepsin L

4. Promiscuous 2-Aminothiazoles (PrATs): A Frequent Hitting Scaffold

5. Rtt109 Acetylates Histone H3 Lysine 56 and Functions in DNA Replication

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