Promiscuous 2-Aminothiazoles (PrATs): A Frequent Hitting Scaffold-Reference-Cited by-同舟云学术

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Promiscuous 2-Aminothiazoles (PrATs): A Frequent Hitting Scaffold

Published:2015-01-16 Issue:3 Volume:58 Page:1205-1214
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Devine Shane M.¹,Mulcair Mark D.¹,Debono Cael O.¹,Leung Eleanor W. W.¹,Nissink J. Willem M.²,Lim San Sui¹,Chandrashekaran Indu R.¹,Vazirani Mansha¹,Mohanty Biswaranjan¹,Simpson Jamie S.¹,Baell Jonathan B.¹,Scammells Peter J.¹,Norton Raymond S.¹,Scanlon Martin J.¹

Affiliation:

1. Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia

2. Oncology iMed, AstraZeneca, Unit 310 − Darwin Building, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, United Kingdom

Funder

National Health and Medical Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm501402x

Reference39 articles.

1. Discovering High-Affinity Ligands for Proteins: SAR by NMR

2. Fragment-Based Drug Discovery

3. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

4. Integrated Strategies for Identifying Leads That Target the NS3 Helicase of the Hepatitis C Virus

5. Fragment screening to predict druggability (ligandability) and lead discovery success

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