Development of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson's disease

Author:

Lesuisse Dominique,Malanda André,Peyronel Jean-François,Evanno Yannick,Lardenois Patrick,De-Peretti Danielle,Abécassis Pierre-Yves,Barnéoud Pascal,Brunel Pascale,Burgevin Marie-Claude,Cegarra Céline,Auger Florian,Dommergue Amélie,Lafon Corinne,Even Luc,Tsi Joanna,Luc Thy Phuong Hieu,Almario Antonio,Olivier Anne,Castel Marie-Noëlle,Taupin Véronique,Rooney Thomas,Vigé Xavier

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference18 articles.

1. Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention;Tansey;Neurobiol Dis,2010

2. Dopamine neuron agenesis in Nurr1-deficient mice;Zetterström;Science,1997

3. Reduced Nurr1 expression increased the vulnerability of mesencephalic dopaminergic neurons to MPTP-induced injury;Le;J Neurochem,1999

4. Age-dependent dopaminergic dysfunction in Nurr1 knock-out mice;Jiang;Exp Neurol,2005

5. A common NURR1 polymorphism associated with Parkinson disease and diffuse Lewy body disease;Zheng;Arch Neurol,2003

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