Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator-Reference-Cited by-同舟云学术

Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator

Published:2013-03 Issue:5 Volume:23 Page:1249-1252
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Hao Junliang,Dehlinger Veronique,Fivush Adam M.,Rudyk Helene C.E.,Britton Thomas C.,Hollinshead Sean P.,Vokits Benjamin P.,Clark Barry P.,Henry Steven S.,Massey Steven M.,Peng Langu,Dressman Bruce A.,Heinz Beverly A.,Roberts Edda F.,Bracey-Walker Mallorie R.,Swanson Steven,Catlow John T.,Love Patrick L.,Tepool Anita D.,Peters Steven C.,Simmons Rosa Maria A.,Iyengar Smriti,McKinzie David L.,Monn James A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference25 articles.

1. Activation of group II mGlu receptors inhibits voltage-gated Ca2+ currents in myenteric neurons

2. Metabotropic Glutamate Receptors Activate G-Protein-Coupled Inwardly Rectifying Potassium Channels inXenopusOocytes

3. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

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