Discovery of ONO-8590580: A novel, potent and selective GABAA α5 negative allosteric modulator for the treatment of cognitive disorders-Reference-Cited by-同舟云学术

Discovery of ONO-8590580: A novel, potent and selective GABAA α5 negative allosteric modulator for the treatment of cognitive disorders

Published:2020-11 Issue:22 Volume:30 Page:127536
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Lewis A.,Beresford A.,Chambers M.S.,Clark G.,Hartley D.C.,Hirst K.L.,Higashino M.,Kawahadara S.,Nakanishi M.,Saito T.,Imagawa A.,Habashita H.,Maidment S.,Macleod A.M.,Owens A.P.,Rae A.,Rouse C.,Wishart G.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference15 articles.

1. [ 3 H]L-655,708, a Novel Ligand Selective for the Benzodiazepine Site of GABA A Receptors which Contain the α5 Subunit

2. In Vitro and in Vivo Properties of 3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA Receptor α5 Subtype-Selective Inverse Agonist

3. An Inverse Agonist Selective for α5 Subunit-Containing GABAA Receptors Enhances Cognition

4. RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors

5. Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABAAReceptor

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1. Identification of Triazolopyridines as Selective α5-GABA_A Receptor Negative Allosteric Modulators by a Hybridization Approach;ACS Chemical Neuroscience;2022-12-16