Discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects-Reference-Cited by-同舟云学术

Discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects

Published:2014-01 Issue:2 Volume:24 Page:526-531
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Sun Shaoyi^ORCID,Zhang Zaihui,Raina Vandna,Pokrovskaia Natalia,Hou Duanjie,Namdari Rostam,Khakh Kuldip,Ratkay Leslie G.,McLaren David G.,Mork Monica,Fu Jianmin,Ferreira Suzie,Hubbard Brian,Winther Michael D.,Dales Natalie

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference34 articles.

1. Modulation of Fatty Acid Metabolism as a Potential Approach to the Treatment of Obesity and the Metabolic Syndrome

2. Lipid oversupply, selective insulin resistance, and lipotoxicity: Molecular mechanisms

3. The regulation of stearoyl-CoA desaturase (SCD)

4. Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss

5. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity

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