Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds-Reference-Cited by-同舟云学术

Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds

Published:2004-02 Issue:4 Volume:14 Page:941-945
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Shen Dong-Ming,Shu Min,Willoughby Christopher A.,Shah Shrenik,Lynch Christopher L.,Hale Jeffrey J.,Mills Sander G.,Chapman Kevin T.,Malkowitz Lorraine,Springer Martin S.,Gould Sandra L.,DeMartino Julie A.,Siciliano Salvatore J.,Lyons Kathy,Pivnichny James V.,Kwei Gloria Y.,Carella Anthony,Carver Gwen,Holmes Karen,Schleif William A.,Danzeisen Renee,Hazuda Daria,Kessler Joseph,Lineberger Janet,Miller Michael D.,Emini Emilio A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference25 articles.

1. Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure–Activity relationships for 1-[N-(Methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes

2. Combinatorial synthesis of CCR5 antagonists

3. 1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements

4. 1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent Anti-HIV activity

5. 1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: Synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV

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