1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent Anti-HIV activity-Reference-Cited by-同舟云学术

1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent Anti-HIV activity

Published:2001-10 Issue:20 Volume:11 Page:2741-2745
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Hale Jeffrey J.,Budhu Richard J.,Holson Edward B.,Finke Paul E.,Oates Bryan,Mills Sander G.,MacCoss Malcolm,Gould Sandra L.,DeMartino Julie A.,Springer Martin S.,Siciliano Salvatore,Malkowitz Lorraine,Schleif William A.,Hazuda Daria,Miller Michael,Kessler Joseph,Danzeisen Renee,Holmes Karen,Lineberger Janet,Carella Anthony,Carver Gwen,Emini Emilio

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference14 articles.

1. HIV-1 entry – an expanding portal for drug discovery

2. Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry

3. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

4. Identification of a major co-receptor for primary isolates of HIV-1

5. A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

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