Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment-Reference-Cited by-同舟云学术

Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment

Published:2004-02 Issue:4 Volume:14 Page:947-952
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Shu Min,Loebach Jennifer L,Parker Kerry A,Mills Sander G,Chapman Kevin T,Shen Dong-Ming,Malkowitz Lorraine,Springer Martin S,Gould Sandra L,DeMartino Julie A,Siciliano Salvatore J,Salvo Jerry Di,Lyons Kathy,Pivnichny James V,Kwei Gloria Y,Carella Anthony,Carver Gwen,Holmes Karen,Schleif William A,Danzeisen Renee,Hazuda Daria,Kessler Joseph,Lineberger Janet,Miller Michael D,Emini Emilio A

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference22 articles.

1. Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure–Activity relationships for 1-[N-(Methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes

2. Combinatorial synthesis of CCR5 antagonists

3. 1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements

4. 1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent Anti-HIV activity

5. 1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: Synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV

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