Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency-Reference-Cited by-同舟云学术

Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency

Published:2015-11 Issue:21 Volume:25 Page:4812-4819
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Egbertson Melissa^ORCID,McGaughey Georgia B.,Pitzenberger Steven M.,Stauffer Shaun R.,Coburn Craig A.,Stachel Shawn J.,Yang Wenjin,Barrow James C.,Neilson Lou Anne,McWherter Melody,Perlow Debra,Fahr Bruce,Munshi Sanjeev,Allison Timothy J.,Holloway Katharine,Selnick Harold G.,Yang ZhiQiang,Swestock John,Simon Adam J.,Sankaranarayanan Sethu,Colussi Dennis,Tugusheva Katherine,Lai Ming-Tain,Pietrak Beth,Haugabook Shari,Jin Lixia,Chen I.-W.,Holahan Marie,Stranieri-Michener Maria,Cook Jacquelynn J.,Vacca Joseph,Graham Samuel L.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference30 articles.

1. http://www.alz.org/facts/downloads/facts_figures_2015.pdf.

2. Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

3. Alzheimer’s Disease

4. Progress toward the development of a viable BACE-1 inhibitor

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