Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: Relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity-Reference-Cited by-同舟云学术

Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: Relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity

Published:2009-08 Issue:16 Volume:19 Page:4542-4545
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Wang Xiaofang,Creek Darren J.,Schiaffo Charles E.,Dong Yuxiang,Chollet Jacques,Scheurer Christian,Wittlin Sergio,Charman Susan A.,Dussault Patrick H.,Wood James K.,Vennerstrom Jonathan L.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference28 articles.

1. Qinghaosu (Artemisinin): The Price of Success

2. Why Artemisinin and Certain Synthetic Peroxides are Potent Antimalarials. Implications for the Mode of Action

3. Artemisinin: mechanisms of action, resistance and toxicity

4. A Medicinal Chemistry Perspective on Artemisinin and Related Endoperoxides

5. Peroxide Bond-Dependent Antiplasmodial Specificity of Artemisinin and OZ277 (RBx11160)

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