Peroxide Bond-Dependent Antiplasmodial Specificity of Artemisinin and OZ277 (RBx11160)-Reference-Cited by-同舟云学术

Peroxide Bond-Dependent Antiplasmodial Specificity of Artemisinin and OZ277 (RBx11160)

Published:2007-08 Issue:8 Volume:51 Page:2991-2993
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kaiser Marcel¹,Wittlin Sergio¹,Nehrbass-Stuedli Angela¹,Dong Yuxiang²,Wang Xiaofang²,Hemphill Andrew³,Matile Hugues⁴,Brun Reto¹,Vennerstrom Jonathan L.²

Affiliation:

1. Swiss Tropical Institute, Socinstrasse 57, CH-4002 Basel, Switzerland

2. College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198-6025

3. Institute of Parasitology, University of Bern, CH-3012 Bern, Switzerland

4. F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, CH-4070 Basel, Switzerland

Abstract

ABSTRACT Using nonperoxidic analogs of artemisinin and OZ277 (RBx11160), the strong in vitro antiplasmodial activities of the latter two compounds were shown to be peroxide bond dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00225-07

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