Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity-Reference-Cited by-同舟云学术

Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity

Published:2009-06 Issue:12 Volume:19 Page:3253-3258
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Walker Daniel P.,Zawistoski Michael P.,McGlynn Molly A.,Li Jian-Cheng,Kung Daniel W.,Bonnette Peter C.,Baumann Amy,Buckbinder Leonard,Houser Janet A.,Boer Jason,Mistry Anil,Han Seungil,Guzman-Perez Li Xing and Angel

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

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3. Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): Structure–activity relationships and strategies for the elimination of reactive metabolite formation

4. Greengrass, P. M.; Stewart, M.; Wood, C. M. Patent Cooperation Treaty WO2003021271, March 13, 2003.

5. [3H]Dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen

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