Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors-Reference-Cited by-同舟云学术

Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors

Published:2009-10 Issue:20 Volume:19 Page:5837-5841
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Giroux André,Boulet Louise,Brideau Christine,Chau Anh,Claveau David,Côté Bernard,Ethier Diane,Frenette Richard,Gagnon Marc,Guay Jocelyne,Guiral Sébastien,Mancini Joseph,Martins Evelyn,Massé Frédéric,Méthot Nathalie,Riendeau Denis,Rubin Joel,Xu Daigen,Yu Hongping,Ducharme Yves,Friesen Richard W.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference20 articles.

1. Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology

2. Reduced Pain Hypersensitivity and Inflammation in Mice Lacking Microsomal Prostaglandin E Synthase-1

3. Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase

4. Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis

5. Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target

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