Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: Identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H1-antihistamines for insomnia-Reference-Cited by-同舟云学术

Lead optimization of 2-(piperidin-3-yl)-1H-benzimidazoles: Identification of 2-morpholin- and 2-thiomorpholin-2-yl-1H-benzimidazoles as selective and CNS penetrating H1-antihistamines for insomnia

Published:2012-01 Issue:1 Volume:22 Page:421-426
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Ravula Satheesh Babu,Yu Jinghua,Tran Joe A.,Arellano Melissa,Tucci Fabio C.,Moree Wilna J.,Li Bin-Feng,Petroski Robert E.,Wen Jianyun,Malany Siobhan,Hoare Samuel R.J.,Madan Ajay,Crowe Paul D.,Beaton Graham

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference12 articles.

1. Sommeil et principaux indicateurs d’insomnie dans la population générale française

2. Oral Nonprescription Treatment for Insomnia: An Evaluation of Products With Limited Evidence

3. Brain-penetrating 2-aminobenzimidazole H1-antihistamines for the treatment of insomnia

Cited by 18 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The recent development of benzimidazole derivative as a promising pharmacological scaffold;Journal of the Indian Chemical Society;2024-09

2. Reaction of 4-Halo-3-hydroxyfuro[3,4-c]pyridin-1(3H)-ones with Morpholine and Thiomorpholine;Russian Journal of Organic Chemistry;2021-03

3. The antagonistic activity of H1 receptor antagonists as medicinal foods;Trends in Food Science & Technology;2020-11

4. Benzimidazole: A Milestone in the Field of Medicinal Chemistry;Mini-Reviews in Medicinal Chemistry;2020-05-18

5. Synthesis of anti-allergic drugs;RSC Advances;2020