Synthesis of xanthone derivatives based on α-mangostin and their biological evaluation for anti-cancer agents
Author:
Funder
Gachon University
Publisher
Elsevier BV
Subject
Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry
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4. Inhibition of cyclooxygenase and prostaglandin E2 synthesis by γ-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells11Abbreviations: AA, arachidonic acid; BSA, bovine serum albumin; COX, cyclooxygenase; COX-1, constitutive COX; COX-2, inducible COX; cPLA2, cytosolic PLA2; EMEM, Eagle’s minimum essential medium; ERK, extracellular signal regulated kinase; HEPES, 2-[4-(2-Hydroxyethyl)-1-piperazinyl]ethanesulfonic acid; MAPK, mitogen-activated protein kinase;PGE2, prostaglandin E2; sPLA2, secretory phospholipase A2; TBST, Tris-buffered saline containing 0.05% Tween 20.
5. Antioxidant Xanthones from the Pericarp of Garcinia mangostana (Mangosteen)
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