Discovery of NR2B-selective antagonists via scaffold hopping and pharmacokinetic profile optimization-Reference-Cited by-同舟云学术

Discovery of NR2B-selective antagonists via scaffold hopping and pharmacokinetic profile optimization

Published:2019-05 Issue:9 Volume:29 Page:1143-1147
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Anan Kosuke,Masui Moriyasu,Tazawa Aya,Tomida Minoru,Haga Yoshihiro,Kume Masaharu,Yamamoto Shoichi,Shinohara Shunji,Tsuji Hiroki,Shimada Shinji,Yagi Shigenori,Hasebe Nobuyoshi,Kai Hiroyuki

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference22 articles.

1. Activation of NR1/NR2B NMDA receptors

2. N-methyl-D-aspartic acid receptor structure and function

3. Cloning and expression of the human NMDA receptor subunit NR3B in the adult human hippocampus

4. Glutamate in CNS disorders as a target for drug development: an update

5. Genetic enhancement of inflammatory pain by forebrain NR2B overexpression

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