N-(3-(Phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: Structure, synthesis and SAR-Reference-Cited by-同舟云学术

N-(3-(Phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: Structure, synthesis and SAR

Published:2008-02 Issue:3 Volume:18 Page:1172-1176
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Deak Holly L.,Newcomb John R.,Nunes Joseph J.,Boucher Christina,Cheng Alan C.,DiMauro Erin F.,Epstein Linda F.,Gallant Paul,Hodous Brian L.,Huang Xin,Lee Josie H.,Patel Vinod F.,Schneider Stephen,Turci Susan M.,Zhu Xiaotian

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference21 articles.

1. Fyn Can Partially Substitute for Lck in T Lymphocyte Development

2. Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

3. Profound block in thymocyte development in mice lacking p56lck

4. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

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