Chemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 1
Author:
Funder
JSPS
Publisher
Elsevier BV
Subject
Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry
Reference28 articles.
1. Structure and Catalytic Properties of Carboxylesterase Isozymes Involved in Metabolic Activation of Prodrugs
2. Genomic Structure and Transcriptional Regulation of the Rat, Mouse, and Human Carboxylesterase Genes
3. THE MAMMALIAN CARBOXYLESTERASES: From Molecules to Functions
4. Structure, function and regulation of carboxylesterases
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1. Prodrugs as empowering tools in drug discovery and development: recent strategic applications of drug delivery solutions to mitigate challenges associated with lead compounds and drug candidates;Chemical Society Reviews;2024
2. Synthesis and evaluation of indomethacin prodrugs with a diester structure that are metabolically activated by human carboxylesterases;Xenobiotica;2023-12-23
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