Alleviating CYP and hERG liabilities by structure optimization of dihydrofuran-fused tricyclic benzo[ d ]imidazole series – Potent, selective and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-2-Reference-Cited by-同舟云学术

Alleviating CYP and hERG liabilities by structure optimization of dihydrofuran-fused tricyclic benzo[ d ]imidazole series – Potent, selective and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-2

Published:2018-04 Issue:7 Volume:28 Page:1211-1218
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Muthukaman Nagarajan,Deshmukh Sanjay,Tambe Macchindra,Pisal Dnyandeo,Tondlekar Shital,Shaikh Mahamadhanif,Sarode Neelam,Kattige Vidya G.,Sawant Pooja,Pisat Monali,Karande Vikas,Honnegowda Srinivasa,Kulkarni Abhay,Behera Dayanidhi,Jadhav Satyawan B.,Sangana Ramchandra R.,Gudi Girish S.,Khairatkar-Joshi Neelima,Gharat Laxmikant A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference72 articles.

1. Molecular Identification of Cytosolic Prostaglandin E2 Synthase That Is Functionally Coupled with Cyclooxygenase-1 in Immediate Prostaglandin E2Biosynthesis

2. Prostanoid Receptors: Structures, Properties, and Functions

3. Prostanoids in nociception and pain

4. Carrageenan-induced Paw Edema in Rat Elicits a Predominant Prostaglandin E2 (PGE2) Response in the Central Nervous System Associated with the Induction of Microsomal PGE2 Synthase-1

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4. Synthesis and Biological Evaluation of 3,4-Dihydro-2H-benzo[b][1,4]-oxazine-2-carboxylic Acid Derivatives as Antitubercular Agents;Asian Journal of Organic & Medicinal Chemistry;2020

5. Microsomal Prostaglandin E2 Synthase-1 as a New Macromolecular Drug Target in the Prevention of Inflammation and Cancer;Anti-Cancer Agents in Medicinal Chemistry;2019-10-24