Design, synthesis, and discovery of 5-((1,3-diphenyl-1 H -pyrazol-4-yl)methylene)pyrimidine-2,4,6(1 H ,3 H ,5 H )-triones and related derivatives as novel inhibitors of mPGES-1-Reference-Cited by-同舟云学术

Design, synthesis, and discovery of 5-((1,3-diphenyl-1 H -pyrazol-4-yl)methylene)pyrimidine-2,4,6(1 H ,3 H ,5 H )-triones and related derivatives as novel inhibitors of mPGES-1

Published:2018-03 Issue:5 Volume:28 Page:858-862
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Ding Kai^ORCID,Zhou Ziyuan,Zhou Shuo,Yuan Yaxia,Kim Kyungbo,Zhang Ting,Zheng Xirong,Zheng Fang,Zhan Chang-Guo^ORCID

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference19 articles.

1. Targeting inflammation: multiple innovative ways to reduce prostaglandin E2

2. The cyclooxygenase isoforms: structural insights into the conversion of arachidonic acid to prostaglandins

3. Prostaglandin E synthase

4. Membrane Prostaglandin E Synthase-1: A Novel Therapeutic Target

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Role of Immune Mechanisms in Abdominal Aortic Aneurysm: Could It be a Promising Therapeutic Strategy?;ACTA CARDIOL SIN;2023

2. Synthesis, in vitro and in silico studies on novel 3-aryloxymethyl-5-[(2-oxo-2-arylethyl)sulfanyl]-1,2,4-triazoles and their oxime derivatives as potent inhibitors of mPGES-1;Journal of Molecular Structure;2023-01

3. In silico investigation of novel 5-benzylidene-2- (arylsulfonylhydrazono)thiazolidine-4-ones as potential inhibitors of mPGES-1 and COX-2.;Journal of Research in Pharmacy;2023

4. Novel 1,2,4-triazoles derived from Ibuprofen: synthesis and in vitro evaluation of their mPGES-1 inhibitory and antiproliferative activity;Molecular Diversity;2022-11-04

5. Development of pharmacotherapies for abdominal aortic aneurysms;Biomedicine & Pharmacotherapy;2022-09