LC–MS-based metabolomics in profiling of drug metabolism and bioactivation
Author:
Publisher
Elsevier BV
Subject
General Pharmacology, Toxicology and Pharmaceutics
Reference54 articles.
1. Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity;Guengerich;Chem Res Toxicol,2001
2. Mechanism of idiosyncratic drug reactions: reactive metabolite formation, protein binding and the regulation of the immune system;Ju;Curr Drug Metab,2002
3. A Strategy to Minimize Reactive Metabolite Formation: Discovery of (S)-4-(1-Cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile as a Potent, Orally Bioavailable Corticotropin-Releasing Factor-1 Receptor Antagonist
4. Bioactivation of drugs: risk and drug design;Walsh;Annu Rev Pharmacol Toxicol,2011
5. A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif;Kalgutkar;Chem Res Toxicol,2007
Cited by 47 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. CYP3A-Mediated Carbon–Carbon Bond Cleavages in Drug Metabolism;Biomolecules;2024-09-05
2. Prediction of cytochrome P450-mediated bioactivation using machine learning models and in vitro validation;Archives of Toxicology;2024-03-16
3. A multivariate data analysis approach for the investigation of in vitro derived metabolites of ACP-105 in comparison with human in vivo metabolites;Journal of Chromatography B;2023-12
4. RT-Ensemble Pred: A tool for retention time prediction of metabolites on different LC-MS systems;Journal of Chromatography A;2023-09
5. Metabolism and Chemical Degradation of New Antidiabetic Drugs: A Review of Analytical Approaches for Analysis of Glutides and Gliflozins;Biomedicines;2023-07-27
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3