A Rational Chemical Intervention Strategy To Circumvent Bioactivation Liabilities Associated with a Nonpeptidyl Thrombopoietin Receptor Agonist Containing a 2-Amino-4-arylthiazole Motif-Reference-Cited by-同舟云学术

A Rational Chemical Intervention Strategy To Circumvent Bioactivation Liabilities Associated with a Nonpeptidyl Thrombopoietin Receptor Agonist Containing a 2-Amino-4-arylthiazole Motif

Published:2007-10-13 Issue:12 Volume:20 Page:1954-1965
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Kalgutkar Amit S.¹,Driscoll James¹,Zhao Sabrina X.¹,Walker Gregory S.¹,Shepard Richard M.¹,Soglia John R.¹,Atherton James¹,Yu Linning¹,Mutlib Abdul E.¹,Munchhof Michael J.¹,Reiter Lawrence A.¹,Jones Christopher S.¹,Doty Johnathan L.¹,Trevena Kristen A.¹,Shaffer Christopher L.¹,Ripp Sharon L.¹

Affiliation:

1. Pharmacokinetics, Dynamics and Metabolism Department, Pfizer Global Research and Development, Groton, Connecticut 06340, and Ann Arbor, Michigan 48105

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx700270r

Reference52 articles.

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3. Thrombopoietin, c-Mpl ligand, induces tyrosine phosphorylation of Tyk2, JAK2, and STAT3, and enhances agonists-induced aggregation in platelets in vitro

4. Thrombopoietin-Induced Activation of the Mitogen-Activated Protein Kinase (MAPK) Pathway in Normal Megakaryocytes: Role in Endomitosis

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