Validated LC–MS/MS method for determination of YH-8, a novel PKnB inhibitor, in rat plasma and its application to pharmacokinetic study-Reference-Cited by-同舟云学术

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Validated LC–MS/MS method for determination of YH-8, a novel PKnB inhibitor, in rat plasma and its application to pharmacokinetic study

Published:2015-09 Issue:5 Volume:5 Page:467-472
ISSN:2211-3835
Container-title:Acta Pharmaceutica Sinica B
language:en
Short-container-title:Acta Pharmaceutica Sinica B

Author:

Zhai Qianqian,Pang Jing,Li Guoqing,Li Congran,Yang Xinyi,Yu Liyan,Wang Yucheng,Li Jian,You Xuefu

Funder

National Mega-Project for Innovative Drugs

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

General Pharmacology, Toxicology and Pharmaceutics

Reference27 articles.

1. The structure of PknB extracellular PASTA domain from Mycobacterium tuberculosis suggests a ligand-dependent kinase activation;Barthe;Structure,2010

2. Structure of Mycobacterium tuberculosis PknB supports a universal activation mechanism for Ser/Thr protein kinases;Young;Nat Struct Mol Biol,2003

3. Expression and characterization of the Mycobacterium tuberculosis serine/threonine protein kinase PknB;Av-Gay;Infect Immun,1999

4. The Ser/Thr protein kinase PknB is essential for sustaining mycobacterial growth;Fernandez;J Bacteriol,2006

5. Auto-activation mechanism of the Mycobacterium tuberculosis PknB receptor Ser/Thr kinase;Mieczkowski;EMBO J,2008

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3. Development and validation of a sensitive LC-MS/MS method for the quantitation of IMB-YH-4py5-2H, an antituberculosis candidate, and its application to the pharmacokinetic study;PLOS ONE;2020-02-19

4. Metabolite profiling of traditional Chinese medicine XIAOPI formula: An integrated strategy based on UPLC-Q-Orbitrap MS combined with network pharmacology analysis;Biomedicine & Pharmacotherapy;2020-01

5. Design, synthesis, and bioevaluation of a novel class of (E)-4-oxo-crotonamide derivatives as potent antituberculosis agents;Bioorganic & Medicinal Chemistry Letters;2019-02

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