Novel 2,4-disubstituted quinazolines as cytotoxic agents and JAK2 inhibitors: Synthesis, in vitro evaluation and molecular dynamics studies-Reference-Cited by-同舟云学术

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Novel 2,4-disubstituted quinazolines as cytotoxic agents and JAK2 inhibitors: Synthesis, in vitro evaluation and molecular dynamics studies

Published:2019-04 Issue: Volume:79 Page:110-118
ISSN:1476-9271
Container-title:Computational Biology and Chemistry
language:en
Short-container-title:Computational Biology and Chemistry

Author:

Jyothi Buggana Siva,Paturi Mani Chandrika,Perka Harathi,Gade Deepak Reddy,VVS Rajendra Prasad

Publisher

Elsevier BV

Subject

Computational Mathematics,Organic Chemistry,Biochemistry,Structural Biology

Reference23 articles.

1. Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden;Abubaker;BMC Cancer,2014

2. Synthesis and antimicrobial activity of some annelated quinazoline derivatives;Aly;J. Chin. Chem. Soc.,2007

3. Chemical characteristics, synthetic methods, and biological potential of quinazoline and quinazolinone derivative;Asif;Int. J. Med. Chem.,2014

4. Activation of JAK2/STAT3 signaling by osteopontin promotes tumor growth in human breast cancer cells;Behera;Carcinogenesis,2010

5. Elucidation of chemo sensitization effect of acridones in cancer cell lines: combined pharmacophore modeling, 3D QSAR, and molecular dynamics studies;Gade;Comput. Biol. Chem.,2018

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4. Nimbolide, a Neem Limonoid, Inhibits Angiogenesis in Breast Cancer by Abrogating Aldose Reductase Mediated IGF-1/PI3K/Akt Signalling;Anti-Cancer Agents in Medicinal Chemistry;2022-08

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