In silico investigation of new binding pocket for mitogen activated kinase kinase (MEK): Development of new promising inhibitors

Author:

Yari Hamed,Ganjalikhany Mohamad Reza,Sadegh Hamidreza

Publisher

Elsevier BV

Subject

Computational Mathematics,Organic Chemistry,Biochemistry,Structural Biology

Reference61 articles.

1. Design and synthesis of orally available MEK inhibitors with potent in vivo antitumor efficacy;Adams;Bioorg. Med. Chem. Lett.,2012

2. Ib and pharmacokinetic study of the MEK inhibitor AZD6244 (ARRY-142886) in patients withadvanced solid tumors;Adjei;J. Clin. Oncol.,2008

3. CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK);Allen;Semin. Oncol.,2003

4. Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase;Anderson;Nature,1990

5. Anti-tumour efficacy of the PI3K inhibitor GDC0941: the dual PI3K/mTOR inhibitor GDC0980 and the MEK inhibitor GDC0973 as single agents and in combination in endometrial carcinomas;Aslan;Eur. J. Cancer,2013

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