Vitamin E treatment in NAFLD patients demonstrates that oxidative stress drives steatosis through upregulation of de-novo lipogenesis

Author:

Podszun Maren C.ORCID,Alawad Ahmad S.,Lingala Shilpa,Morris Nevitt,Huang Wen-Chun A.,Yang Shanna,Schoenfeld Megan,Rolt Adam,Ouwerkerk Ronald,Valdez Kristin,Umarova Regina,Ma Yanling,Fatima Syeda ZaheenORCID,Lin Dennis D.,Mahajan Lakshmi S.ORCID,Samala Niharika,Violet Pierre-ChristianORCID,Levine Mark,Shamburek Robert,Gharib Ahmed M.,Kleiner David E.,Garraffo H. Martin,Cai Hongyi,Walter Peter J.ORCID,Rotman YaronORCID

Funder

Office of Dietary Supplements

National Cancer Institute

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

Elsevier BV

Subject

Organic Chemistry,Biochemistry,Clinical Biochemistry

Reference54 articles.

1. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention;Younossi;Nat. Rev. Gastroenterol. Hepatol.,2018

2. Role of oxidative stress in pathophysiology of nonalcoholic fatty liver disease;Masarone;Oxid. Med. Cell. Longev.,2018

3. First proof that vitamin E is major lipid-soluble, chain-breaking antioxidant in human blood plasma;Burton;Lancet (North Am. Ed.),1982

4. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids,2000

5. Vitamin E and its functions in membranes;Wang;Prog. Lipid Res.,1999

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