Novel, selective acrylamide linked quinazolines for the treatment of double mutant EGFR-L858R/T790M Non-Small-Cell lung cancer (NSCLC)

Author:

Pawara Rahul,Ahmad Iqrar,Nayak Deepika,Wagh Shivani,Wadkar Avinash,Ansari Azim,Belamkar Sateesh,Surana Sanjay,Nath Kundu Chanakya,Patil Chandragauda,Patel Harun

Funder

Ministry of Health and Family Welfare

Indian Council of Medical Research

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference72 articles.

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2. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship;Molina;Mayo Clin. Proc.,2008

3. In-Silico Evidences for Binding of Glucokinase Activators to EGFR C797S to Overcome EGFR Resistance Obstacle with Mutant-Selective Allosteric Inhibition;Patel;Comput. Biol. Chem.,2018

4. p38α MAP kinase inhibitors to overcome EGFR tertiary C797S point mutation associated with osimertinib in non-small cell lung cancer (NSCLC): emergence of fourth-generation EGFR inhibitor;Ahmad;J. Biomol. Struct. Dyn.,2020

5. Role of receptor tyrosine kinases in lung cancer;Maulik;Methods Mol. Med.,2003

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