Design, Synthesis, biological Evaluation, and molecular docking studies of novel Pyrazolo[3,4-d]Pyrimidine derivative scaffolds as potent EGFR inhibitors and cell apoptosis inducers
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry
Reference45 articles.
1. Synthesis and antitumor activity of ureas containing pyrimidinyl group;Jin;Eur. J. Med. Chem.,2011
2. Targeted therapy and chechpoint immunotherapy in lung cancer;Ruiz-Cordero;Surg. Pathol. Clin.,2020
3. In vitro assessment of antitumor potential and combination effect of classical and molecular-targeted anticancer drugs;Iijima;Anticancer Res.,2019
4. Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy;Sierra;Mol. Cancer.,2010
5. Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles;Arris;J. Med. Chem.,2000
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