Hydrophobic substituents on isatin derivatives enhance their inhibition against bacterial peptidoglycan glycosyltransferase activity

Author:

Wang Yong,Cheong Wing-Lam,Liang Zhiguang,So Lok-Yan,Chan Kin-Fai,So Pui-Kin,Chen Yu Wai,Wong Wing-Leung,Wong Kwok-Yin

Funder

Hong Kong Research Grants Council

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference40 articles.

1. WHO report on surveillance of antibiotic consumption: 2016-2018 early implementation, 2018.

2. Tackling drug-resistant infections globally: final report and recommendations;O’Neill;Rev. Antimicrob. Resist.,2016

3. Bacterial transglycosylase inhibitors;Ostash;Curr. Opin. Chem. Biol.,2005

4. Crystal structure of Staphylococcus aureus transglycosylase in complex with a lipid II analog and elucidation of peptidoglycan synthesis mechanism;Huang;Proc. Natl. Acad. Sci. USA,2012

5. Crystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli;Sung;Proc. Natl. Acad. Sci. USA,2009

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