Design, synthesis and biological evaluation of substituted 2-(thiophen-2-yl)-1,3,5-triazine derivatives as potential dual PI3Kα/mTOR inhibitors-Reference-Cited by-同舟云学术

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Design, synthesis and biological evaluation of substituted 2-(thiophen-2-yl)-1,3,5-triazine derivatives as potential dual PI3Kα/mTOR inhibitors

Published:2020-01 Issue: Volume:95 Page:103525
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Zhang Binliang,Zhang Qian,Xiao Zhen,Sun Xin,Yang Zunhua,Gu Qi,Liu Ziqin,Xie Ting,Jin Qingqing,Zheng Pengwu,Xu Shan,Zhu Wufu

Funder

The National Natural Science Funds of China

Natural Science Foundation of Jiangxi, China

Education Department of Jiangxi Province

Jiangxi Science and Technology Normal University Innovative Research Team

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference20 articles.

1. Design, synthesis and docking studies of novel thienopyrimidine derivatives bearing chromone moiety as mTOR/PI3Kα inhibitors;Zhu;Eur. J. Med. Chem.,2015

2. Synthesis and Biological Evaluation of Novel 8-Morpholinoimidazo [1,2-a]pyrazine Derivatives Bearing Phenylpyridine/Phenylpyrimidine-Carboxamides;Xu;Molecules,2017

3. Synthesis and anticancer activity of novel 4-morpholino-7,8-dihydro-5H- thiopyrano[4,3-d]pyrimidine derivatives bearing chromone moiety;Sun;Bioorg. Med. Chem.,2016

4. Synthesis and Structure-Activity Relationships of 4-Morpholino-7,8- Dihydro-5H-Thiopyrano[4,3-d]pyrimidine Derivatives Bearing Pyrazoline Scaffold;Wang;Molecules,2017

5. A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-specific Inhibitor, with Letrozole in ER+/HER2-Negative Metastatic Breast Cancer;Mayer;Clin. Cancer Res.,2016

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