Design, synthesis and docking studies of novel thienopyrimidine derivatives bearing chromone moiety as mTOR/PI3Kα inhibitors-Reference-Cited by-同舟云学术

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Design, synthesis and docking studies of novel thienopyrimidine derivatives bearing chromone moiety as mTOR/PI3Kα inhibitors

Published:2015-03 Issue: Volume:93 Page:64-73
ISSN:0223-5234
Container-title:European Journal of Medicinal Chemistry
language:en
Short-container-title:European Journal of Medicinal Chemistry

Author:

Zhu Wufu,Chen Chen,Sun Chengyu,Xu Shan,Wu Chunjiang,Lei Fei,Xia Hui,Tu Qidong,Zheng Pengwu

Funder

National Natural Science Funds of China

Natural Science Foundation of Jiangxi Province

Doctoral Scientific Research Foundation of Jiangxi Science & Technology Normal University

Key Laboratory of Drug Design and Optimization,Jiangxi Science & Technology Normal University

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference16 articles.

1. Development of PI3K inhibitors: lessons learned from early clinical trials

2. PI3K Pathway Inhibitors: Better Not Left Alone

3. Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor

4. Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer

5. The Identification of 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer

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1. PI3Kδ and mTOR dual inhibitors: Design, synthesis and anticancer evaluation of 3-substituted aminomethylquinoline analogues;Bioorganic Chemistry;2024-06

2. Designing of target‐specific N‐substituted tetrahydroquinoline derivatives as potent mTOR inhibitors via integrated structure‐guided computational approaches;ChemistrySelect;2024-02-14

3. New Hybrid Cytisine Derivatives Containing a Thienopyrimidine Fragment;Chemistry of Natural Compounds;2024-01

4. Recent advancement in pyrrolidine moiety for the management of cancer: A review;Results in Chemistry;2024-01

5. Pyrazine Moiety: Recent Developments in Cancer Treatment;Current Organic Chemistry;2023-05

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