Structure-based screening and biological validation of the anti-thrombotic drug-dicoumarol as a novel and potent PPARγ-modulating ligand-Reference-Cited by-同舟云学术

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Structure-based screening and biological validation of the anti-thrombotic drug-dicoumarol as a novel and potent PPARγ-modulating ligand

Published:2022-12 Issue: Volume:129 Page:106191
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Ma Lei,Tang Junyuan,Cai Guihui,Chen Fangyuan,Liu Qingmei,Zhou Zhi,Zhang Silin,Liu Xiawen,Hou Ning,Yi Wei

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference67 articles.

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2. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications;Zheng;Nat. Rev. Endocrinol.,2018

3. Leptin, cardiovascular diseases and type 2 diabetes mellitus;Katsiki;Acta Pharmacol. Sin.,2018

4. Non-alcoholic Fatty Liver Disease and Diabetes Mellitus;Khneizer;Adv. Exp. Med. Biol.,2021

5. Novel therapies with precision mechanisms for type 2 diabetes mellitus;Perreault;Nat. Rev. Endocrinol.,2021

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1. Structure-based screening, optimization and biological evaluation of novel chrysin-based derivatives as selective PPARγ modulators for the treatment of T2DM and hepatic steatosis;European Journal of Medicinal Chemistry;2024-10

2. Raloxifene-driven benzothiophene derivatives: Discovery, structural refinement, and biological evaluation as potent PPARγ modulators based on drug repurposing;European Journal of Medicinal Chemistry;2024-04

3. Isocyanide-based multicomponent reactions for the synthesis of benzopyran derivatives with biological scaffolds;Organic & Biomolecular Chemistry;2024

4. Rational design of thiazolidine-4-one-gallic acid hybrid derivatives as selective partial PPARγ modulators: an in-silico approach for type 2 diabetes treatment;Journal of Biomolecular Structure and Dynamics;2023-11-24

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