Identification of novel 3-aryl-1-aminoisoquinolines-based KRASG12C inhibitors: Rational drug design and expedient construction by C H functionalization/annulation-Reference-Cited by-同舟云学术

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Identification of novel 3-aryl-1-aminoisoquinolines-based KRASG12C inhibitors: Rational drug design and expedient construction by C H functionalization/annulation

Published:2024-01 Issue: Volume:142 Page:106954
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Gong Zirong,Zhao Yu,Xu Buyi,Yang Zhou,Ren Boquan,Yang Han^ORCID,Zeng Chengfu,Chen Renqiang,Xu Yan-Jun,Li Qing^ORCID

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference66 articles.

1. An analysis of successful hit-to-clinical candidate pairs;Brown;J. Med. Chem.,2023

2. Recent scaffold hopping applications in central nervous system drug discovery;Callis;J. Med. Chem.,2022

3. The rise and fall of a scaffold: a trend analysis of scaffolds in the medicinal chemistry literature;Zdrazil;J. Med. Chem.,2018

4. Analysis of past and present synthetic methodologies on medicinal chemistry: where have all the new reactions gone?;Brown;J. Med. Chem.,2016

5. Bridging the gap between natural product synthesis and drug discovery;Truax;Nat. Prod. Rep.,2020

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Assembly of Selenadiazine Scaffolds via Rh(III)-Catalyzed Amidine-Directed Cascade C–H Selenylation/[5 + 1] Annulation with Elemental Selenium;Organic Letters;2024-08-01

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