1H-Indazoles derivatives targeting PI3K/AKT/mTOR pathway: Synthesis, anti-tumor effect and molecular mechanism

Author:

Wang Shuai,Shi Jian-Tao,Wang Xing-Rong,Mu Hong-Xia,Wang Xue-Ting,Xu Kai-Yan,Wang Qing-Shan,Chen Shi-Wu

Funder

Lanzhou University

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference39 articles.

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2. Momordica charantia-derived extracellular vesicles-like nanovesicles inhibited glioma proliferation, migration, and invasion by regulating the PI3K/AKT signaling pathway;Wang;J. Funct. Foods,2022

3. Intracellular MUC20 variant 2 maintains mitochondrial calcium homeostasis and enhances drug resistance in gastric cancer;Fu;Gastric Cancer,2022

4. Role of mammalian target of rapamycin complex 2 in primary and secondary liver cancer, World J. Gastrointest;Joechle;Oncol.,2021

5. Cetin-Atalay, Targeting PI3K/Akt/mTOR pathway identifies differential expression and functional role of IL8 in liver cancer stem cell enrichment;Kahraman;Mol. Cancer. Ther.,2019

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