Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo
Author:
Funder
Japan Society for the Promotion of Science
Publisher
Elsevier BV
Subject
Pharmacology (medical),Pharmaceutical Science,Pharmacology
Reference12 articles.
1. U.S. FDA approved drugs from 2015–june 2020: a perspective;Bhutani;J Med Chem,2021
2. Drug interactions between nine antifungal agents and drugs metabolized by human cytochromes P450;Niwa;Curr Drug Metabol,2014
3. Potential impact of cytochrome P450 3A5 in human liver on drug interactions with triazoles;Yamazaki;Br J Clin Pharmacol,2010
4. CYP3A5 Contributes significantly to CYP3A-mediated drug oxidations in liver microsomes from Japanese subjects;Yamaori;Drug Metabol Pharmacokinet,2004
5. Novel, potent, and selective phosphodiesterase 5 inhibitors: synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives;Ukita;J Med Chem,2001
Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. HepaSH cells: Experimental human hepatocytes with lesser inter-individual variation and more sustainable availability than primary human hepatocytes;Biochemical and Biophysical Research Communications;2023-06
2. High hepatic and plasma exposures of atorvastatin in subjects harboring impaired cytochrome P450 3A4∗16 modeled after virtual administrations and possibly associated with statin intolerance found in the Japanese adverse drug event report database;Drug Metabolism and Pharmacokinetics;2023-04
3. Cytochrome P450s in chimeric mice with humanized liver;Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary;2022
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3